Figure 2.
Salmonella treatment retards MC38 tumor growth. MC38 tumor cells (2× 105) were subcutaneously implanted into the right flank of C57BL/6 mice. Seven days post implantation, mice were injected intraperitoneally with either Salmonella strain BRD509E (~5× 103 CFUs) or saline as control. (A) Tumor volumes were measured twice a week for up to 14 days post bacterial treatment. The data is shown as mean ± SEM of 9-12 mice per group, pooled from 2 independent experiments. (B) Tumor weights were recorded at the end of the observation period (day 21 post implantation). Each data point represents a single mouse, pooled from two independent experiments. (C) Tumor growth curves in each individual mouse in the control and BRD509E-treated groups are presented. (D) The effect of BRD509E treatment on the survival of MC38 tumor-bearing mice. Asterisks denote statistically significant differences from control group *(P ≤ 0.05) and ** (P ≤ 0.01).