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. 2022 Dec 20;13:1017780. doi: 10.3389/fimmu.2022.1017780

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Copyright © 2022 Al-Saafeen, Al-Sbiei, Bashir, Mohamed, Masad, Fernandez-Cabezudo and al-Ramadi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The combination of αPD-L1 and Salmonella enhances the infiltration of CD45⁺ immune cells into MC38 tumors. MC38 tumor-bearing mice were treated with αPD-L1 or combination of Salmonella and αPD-L1 or isotype control. On day 21 post tumor implantation, mice were sacrificed, tumors were collected and the percentage of CD45⁺ cells were determined using flow cytometry. (A) Representative dot plots showing the percentage of CD45⁺ cells out of MC38 tumors in control, αPD-L1 and combination-treated groups. (B) Quantification of the percentage of CD45⁺ immune cells in the three groups. The correlation between tumor volumes and the infiltration of CD45⁺ cells is illustrated (C). Each data point in (B) represents a single mouse, pooled from 2 independent experiments. Each data point in (C) represents a single mouse, pooled from 3 independent experiments for control and αPD-L1-treated groups and from 2 independent experiments for combination-treated group. Asterisks denote statistically significant differences from control group, * (P ≤ 0.05) and ** (P ≤ 0.01).