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. 2022 Dec 20;12:1049065. doi: 10.3389/fcimb.2022.1049065

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Copyright © 2022 Healer, Thompson, Mackwell, Browne, Seager, Ngo, Lowes, Silk, Pulido, King, Christen, Noe, Kotraiah, Masendycz, Rajagopalan, Lucas, Stanford, Soisson, Diggs, Miller, Youll, Wycherley, Draper and Cowman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DPX-formulated candidates induce P. falciparum growth inhibitory antibodies against RH5, CyRPA and Ripr in mice and rats. (A) A GIA assay was performed with IgG pooled from 6 mice immunized with 20 μg antigen formulated with DPX - RH5 (red squares), CyRPA (green triangles) or Ripr (blue circles). Intra-cohort variability in GIA of IgG from six individual rats immunized with 2 μg antigen - RH5.1 (B) CyRPA (C) and Ripr (D) antigens were formulated with DPX. Error bars represent SEM of triplicate wells.