TABLE 1.

Profile of the different cannabinoids and drugs that act on the cannabinoid system that may be effective in the treatment of audiovestibular disorders.

Drug and properties		Targets
	Name: Anandamide IUPAC name: (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide Molecular mass: 347.53 g·mol−1 Molecular formula: C22H37NO2 Category: Endocannabinoids	Agonists CB1; TRPV1
	Name: 2-Arachidonoylglycerol (2-AG) IUPAC name: 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate Molecular mass: 378.3 g·mol−1 Molecular formula: C23H38O4 Category: Endocannabinoids	Agonists CB1; CB2
	Name: 2-Arachidonyl glyceryl ether (2-AGE; Noladin ether) IUPAC name: 2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]propane-1,3-diol Category: Endocannabinoids Molecular mass: 364.56 g·mol−1 Molecular formula: C23H40O3	Agonists CB1; CB2 (weak)
	Name: N-Arachidonoyl dopamine (NADA) IUPAC name: (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide Molecular mass: 439.63 g·mol−1 Molecular formula: C28H41NO3 Category: Endocannabinoids	Agonists CB1; TRPV1
	Name: Virodhamine (O-arachidonoyl ethanolamine; O-AEA) IUPAC name: 2-aminoethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate Molecular mass: 347.53 g·mol−1 Molecular formula: C22H37NO2 Category: Endocannabinoids	Agonists CB2	Antagonists CB1
	Name: Lysophosphatidylinositol (LPI, lysoPI) IUPAC name: [(2S)-2-hydroxy-3-[hydroxy-[(2R,3S,5R,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxypropyl] acetate Molar mass: 572.629 g·mol−1 Molecular formula: C25H49O12P Category: Endocannabinoids	Agonists GPR55
	Name: THC/Dronabinol IUPAC name: (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo [c]chromen-1-ol Molar mass: 314.469 g·mol−1 Molecular formula: C21H30O2 Category: Phytocannabinoids/Synthetic cannabinoids	Agonists CB1; CB2
	Name: Cannabidiol IUPAC name: 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol Molar mass: 314.469 g·mol−1 Molecular formula: C21H30O2 Category: Phytocannabinoids	Agonists HTR1A; HTR2A; TRPA1	Activators PPARG; TRPV1; TRPV2; TRPV3; TRPV4; ADORA1
		Inverse agonists GPR12
			Inhibitors PTGS1; PTGS2; ACAT1; IDO1; NQO1; CAT; SOD; AANAT; NAAA
		Antagonists CB1; CB2; GPR55; HTR3A
			Stimulators HMGCR; GSR; GSR; GPX
		Modulators CB1
			Other targets GLRA1; GPR18; CHRNA7; OPRD1; OPRM1; CACNA1G CACNA1H; CACNA1I; TRPM8; VDAC1
		Potentiators GLRA3
	Name: CP 55,940 IUPAC name: 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol Molar mass: 376.581 g·mol−1 Molecular formula: C24H40O3 Category: Synthetic cannabinoids	Agonists CB1; CB2; HTR5A	Antagonists GPR55
	Name: Nabilone IUPAC name: (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo [c]chromen-9-one Molar mass: 372.549 g·mol−1 Molecular formula: C24H36O3 Category: Synthetic cannabinoids	Agonists CB1 (partial); CB2 (partial)
	Name: JWH-015 IUPAC name: (2-methyl-1-propylindol-3-yl)-naphthalen-1-ylmethanone Molar mass: 327.427 g·mol−1 Molecular formula: C23H21NO Category: Synthetic cannabinoids	Agonists CB2; CB1 (weak)
	Name: Dimethylbutyl-deoxy-Delta-8-THC (JWH-133) IUPAC name: (6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydrobenzo [c]chromene Molar mass: 312.497 g·mol−1 Molecular formula: C22H32O Category: Synthetic cannabinoids	Agonists CB2
	Name: WIN55,212–2 IUPAC name: [(11R)-2-methyl-11-(morpholin-4-ylmethyl)-9-oxa-1-azatricyclo [6.3.1.04,12]dodeca-2,4 (12),5,7-tetraen-3-yl]-naphthalen-1-ylmethanone Molar mass: 338.407 g•mol−1 Molecular formula: C20H22N2O3 Category: Synthetic cannabinoids	Agonists CB1; CB2; PPARα; PARγ
	Name: URB597 (KDS-4103) IUPAC name: [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate Molar mass: 338.407 g•mol−1 Molecular formula: C20H22N2O3 Category: Endocannabinoid reuptake inhibitor	Inhibitor FAAH
	Name: URB937 IUPAC name: N-cyclohexyl-carbamic acid, 3'-(aminocarbonyl)-6-hydroxy [1,1′-biphenyl]-3-yl ester Molar mass: 338.407 g•mol−1 Molecular formula: C20H22N2O4 Category: Endocannabinoid reuptake inhibitor	Inhibitor FAAH
	Name: AM374 IUPAC name: Hexadecanesulfonyl fluoride Molar mass: 308.219 g•mol−1 Molecular formula: C16H33FO2S Category: Endocannabinoid reuptake inhibitor	Inhibitor FAAH
		Other targets PPT1
	Name: JZL195 IUPAC name: 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate Molar mass: 433.464 g•mol−1 Molecular formula: C24H23N3O5 Category: Endocannabinoid reuptake inhibitor	Inhibitor FAAH; MAGL
Name: Dietressa© Category: Synthetic cannabinoid antibodies		Antagonists CB1
Name: Brizantin© Category: Synthetic cannabinoid antibodies		Antagonists CB1