Figure 4. Seroconversion in cynomolgus macaques infected with SARS-CoV-2 Delta variant. (A) SARS-CoV-2 spike (S1+S2) protein specific IgM, IgG, IgA antibodies were measured by ELISA at 0, 3, 7, 14, 21 dpi and fold change in IgM, IgG and IgA antibodies was determined by dividing with baseline (0 dpi). (B) SARS-CoV-2 RBD specific IgM, IgG, IgA antibodies were measured by ELISA at same time points and fold change in IgM, IgG, and IgA antibody was determined by dividing with baseline (0 dpi). n=6 at 0, 3 dpi; n=3 at 7, 14, 21 dpi. Circles indicate individual data measured from macaques and bars show the group mean±SEM. One-way ANOVA with Tukey’s multiple comparison test.

^*p<0.05, ^**p<0.001, ^***p<0.0001.