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. 2022 Dec 20;12:993611. doi: 10.3389/fonc.2022.993611

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Copyright © 2022 Tintelnot, Ristow, Sauer, Simnica, Schultheiß, Scholz, Goekkurt, von Wenserski, Willscher, Paschold, Lorenzen, Riera-Knorrenschild, Depenbusch, Ettrich, Dörfel, Al-Batran, Karthaus, Pelzer, Hinke, Bauer, Massa, Seliger, Wickenhauser, Bokemeyer, Hegewisch-Becker, Binder and Stein

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Multi linear correlation analysis of indicated markers with the best radiological response. Shannon diversity of TiLs (B) or clonality of TiLs (C) was correlated with radiological response. Shannon diversity of baseline (BL) PBMCs (D) or PBMCs after three cycles of chemotherapy (E) was correlated with radiological response. (F) The analyzed cohort was separated into patients having a higher than median TiL diversity vs. lower TiL diversity. Overall survival is shown in the Kaplan-Meier estimator. Multi linear correlation and Pearsons´s r (A), simple linear regression (B–E) or log-rank Mantel-cox test (F) was calculated. P values are indicated.