Fig. 4.

10× magnification FOVs with proper and improper false negatives.

4A. A 10× FOV which contains numerous false negative ROIs, which are indicated by the red boxes (ground-truth cancer) inscribed with green circles (machine disagreement with ground truth).

4B. An immunostain of the FOV in 4A. Brown regions of the immunostain indicate cancer. The immunostain confirms the ground truth of the central region, thus the ROIs within this region are proper false negatives.

4C. A 10× FOV which contains improper false-negative ROIs due to the over-labeling of cancer by our annotating pathologist. On review, the annotating pathologist agreed that many of the above false negatives were improper.

4D. An immunostain of the FOV in 4C. This immunostain confirms the over-labeling of cancer.