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. 2022 Dec 20;12:1084683. doi: 10.3389/fonc.2022.1084683

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Copyright © 2022 Chen, Han, Zheng, Yang, Li, Zhang, Yang, Dong, He, He and Cai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of LDH on progression-free survival (PFS) and overall survival (OS) of patients with myeloma: LDH and 1q gain have an adverse effect on the survival (both PFS and OS) of MM patients independently. Patients with co-occurrence of LDH>UNL and 1q gain (the green curve) had the worst survival while those without LDH nor 1q abnormal (the blue curve) had the most favorable survival. Patients with LDH>UNL or 1q gain (the red curve) showed intermediate compared with patients mentioned above. (A). Progression-free survival. (B). Overall survival.