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. 2022 Dec 20;13:1072720. doi: 10.3389/fimmu.2022.1072720

Figure 4.

Figure 4

Fecal solutes from MSM with HIV infection increase transcellular gut epithelial permeability and associate with sIFs. (A) The change in short circuit current (ΔIsc) after 4 hours was calculated using Ohm’s law. A Kruskal-Wallis test was performed to determine statistical significance where * = p < 0.05, ** = p < 0.01, and *** = p < 0.001. Correlations between ΔIsc and sIF PC1 values from PCoA from figure 3 for all (B), HIV (C), and HIV-ART (D) participants. Each point represents data from one participant and are colored based on cohort: non-MSM-SN (dark blue), MSM-SN (green), MSM-ART (orange) and MSM-HIV (red). Each black line represents the linear regression for all included points, and P- and R-values are associated with this line. Each dotted line represents the linear regression for the cohort with the corresponding color. (E) A heat map showing associations between sIF concentrations and 4 hour ΔIsc. Teal indicates a negative R-value whereas orange represents a positive R-value. Rank order spearman correlations were run to determine statistical significance where * = p < 0.05, ** = p < 0.01, and *** = p < 0.001.