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. 2022 Dec 20;13:1062225. doi: 10.3389/fimmu.2022.1062225

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Copyright © 2022 Khan, Ai, Du, Song, Wang, Lin, Ren, Chen, Huang, Qiu, Zhang, Tian and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic & epigenetic aberrations in PRGs. (A) Histogram illustrates frequency of copy number alteration (deletion/amplification) for each PRG across cancers. (B) The Spearman’s correlation between copy number variation (CNV) and the expression of PRGs. Blue & red represent negative & positive correlation respectively. (C) Heatmap shows the methylation difference between tumor and normal tissues. Red and blue indicate hypermethylation and hypomethylation in cancers, respectively. (D) Pearson’s correlation showing association between methylation and gene expression. Blue & red represent negative & positive correlation respectively.