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. 2022 Dec 20;13:1062225. doi: 10.3389/fimmu.2022.1062225

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Copyright © 2022 Khan, Ai, Du, Song, Wang, Lin, Ren, Chen, Huang, Qiu, Zhang, Tian and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic vulnerabilities. (A) Spider web plot summarizes spearman correlation between pyroptosis level and tumor mutation burden. * p value < 0.05; ** p value < 0.01; *** p value < 0.001. (B) Spider web plot summarizes spearman correlation between pyroptosis level and microsatellite instability. * p value < 0.05; ** p value < 0.01; *** p value < 0.001. (C) Enrichment analysis for hallmark cancer pathways between pyroptosis-high and pyroptosis-low tumor tissues. NES is the normalized enrichment score in the GSEA algorithm. (D) Drug sensitivity analysis of PRGs based on the CellMiner database. Green depicts negative correlation (sensitivity to drug) and red shows positive correlation (induction of gene expression).