Table 1.
Demographics and tumor characteristics—all enrolled patients
| Overall n = 69 | |
|---|---|
| Age (years)—median (Q1-Q3) | 69.9 (65.0-76.3) |
| Min-max | 44.5-82.8 |
| Female sex | 25 (36.2) |
| ECOG performance status | |
| 0 | 43 (62.3) |
| 1 | 26 (37.7) |
| Body mass index (kg/m2)—median (Q1-Q3) | 25.0 (22.4-27.4) |
| Min-max | 17.8-38.6 |
| Comorbidities | 58 (85.3) |
| Missing | 1 |
| Concomitant medications for comorbidities | 46 (90.2) |
| Missing | 7 |
| Concomitant medication for MPM | 28 (40.6) |
| ECG findings | |
| Clinically relevant findings | 3 (4.3) |
| No clinically relevant findings | 66 (95.7) |
| Asbestos exposure | 39 (57.4) |
| Missing | 1 |
| Smoking history | 31 (45.6) |
| Tumor sites at first diagnosis | |
| Pleura | 42 (62.7) |
| Pleura, lymph node | 13 (19.4) |
| Pleura, lung | 4 (6.0) |
| Pleura, lung, lymph node | 2 (3.0) |
| Lung | 1 (1.5) |
| Pleura, adrenal glands, other (mediastinum) | 1 (1.5) |
| Pleura, bone, lymph node | 1 (1.5) |
| Pleura, other (pleural effusion) | 1 (1.5) |
| Pleura, other (mediastinal) | 1 (1.5) |
| Pleura, other (peritoneal carcinomatosis) | 1 (1.5) |
| Missing | 2 |
| Histotype | |
| Epithelioid | 62 (89.9) |
| Biphasic | 4 (5.8) |
| Sarcomatoid | 3 (4.3) |
| Anatomical stage group | |
| I | 1 (2.2) |
| II | 4 (8.7) |
| III | 11 (23.9) |
| IV | 30 (65.2) |
| Missing | 23 |
| First-line chemotherapy type | |
| Carboplatin/pemetrexed | 42 (60.9) |
| Cisplatin/pemetrexed | 27 (39.1) |
| Number of cycles of first-line chemotherapy | |
| 2 | 2 (2.9) |
| 3 | 7 (10.1) |
| 4 | 17 (24.6) |
| 5 | 4 (5.8) |
| 6 | 39 (56.5) |
| Best tumor response of first-line chemotherapy | |
| SD | 36 (53.7) |
| PR | 18 (26.9) |
| PD | 13 (19.4) |
| Missing | 2 |
| Surgery carried out | |
| No | 44 (68.8) |
| Yes | 20 (31.3) |
| Missing | 5 |
| Surgery type | |
| Pleural decortication/pleurectomy (PD) | 10 (50.0) |
| Other (diagnostic video-assisted thoracoscopy) | 2 (10.0) |
| Other (VATS) | 2 (10.0) |
| Extrapleural pneumonectomy (EPP) | 1 (5.0) |
| Other (diagnostic video-assisted thoracoscopy) | 1 (5.0) |
| Other (videothoracoscopy) | 1 (5.0) |
| Other (diagnostic video-assisted thoracoscopy) | 1 (5.0) |
| Other (removal of tumor and ribs X-XI-XII) | 1 (5.0) |
| Other (thoracotomy) | 1 (5.0) |
| Talc pleurodesis | |
| No | 7 (38.9) |
| Yes | 11 (61.1) |
| Missing | 2 |
ECG, electrocardiogram; ECOG, Eastern Cooperative Oncology Group; MPM, malignant pleural mesothelioma; PD, progressive disease; PR, partial response; Q1-Q3, first and third quartile; SD, stable disease; VATS, video-assisted thoracoscopic surgery.