Table 2.

Interaction between HFDS and anticancer treatments found in the study with the application

Patient’s study number	HFDS	Cancer treatment	CYP involved	CYP modification	Level	Supervised	Auto-implementation	Food questionnaire	HFDS type	HFDI category
3	Green tea	Vinorelbine	CYP3A	Inhibition	3	Yes	No	No	Herb	Probable
30	Green tea	Paclitaxel	CYP3A	Inhibition	3	No	Yes	Yes	Food	Probable
	Licorice	Paclitaxel	CYP3A	Induction	1	No	Yes	Yes	Food	Probable
36	Green tea	Letrozole	CYP3A	Inhibition	3	No	Yes	Yes	Food	Probable
38	Cranberry	Paclitaxel	CYP3A	Inhibition	2	No	Yes	Yes	Food	Probable
	Grapefruit	Paclitaxel	CYP3A	Inhibition	1	No	Yes	Yes	Food	Probable
40	Coffee	Cyclophosphamide	CYP1A2	Inhibition	2	No	Yes	Yes	Food	Probable
44	Green tea	Trastuzumab-emtansine	CYP3A	Inhibition	3	No	Yes	Yes	Food	Probable
46	Green tea	Paclitaxel	CYP3A	Inhibition	3	No	Yes	Yes	Food	Probable
55	Coffee	Cyclophosphamide	CYP1A2	Inhibition	2	No	Yes	Yes	Food	Probable
60	Peppermint	Lenvatinib	CYP3A	Inhibition	2	No	Yes	No	Herb	Probable
	Green tea	Lenvatinib	CYP3A	Inhibition	2	No	Yes	Yes	Food	Probable
71	Grapefruit	Dexamethasone	CYP3A	Inhibition	1	Yes	Yes	Yes	Food	Probable
73	Cranberry	Lapatinib	CYP3A	Inhibition	2	No	Yes	Yes	Food	Probable
78	Green tea	Ibrutinib	CYP3A	Inhibition	3	Yes	Yes	Yes	Food	Probable
79	Green tea	Vinblastine	CYP3A	Inhibition	3	Yes	Yes	Yes	Food	Probable
	Pomelo	Vinblastine	CYP3A	Inhibition	3	Yes	Yes	Yes	Food	Probable
85	Coffee	Cyclophosphamide	CYP1A2	Inhibition	2	Yes	Yes	Yes	Food	Probable
87	Green tea	Vinblastine	CYP3A	Inhibition	3	No	Yes	Yes	Food	Probable
	Pomelo	Vinblastine	CYP3A	Inhibition	3	No	Yes	Yes	Food	Probable
	Grapefruit	Vinblastine	CYP3A	Inhibition	1	No	Yes	Yes	Food	Probable
89	Coffee	Cyclophosphamide	CYP1A2	Inhibition	2	No	Yes	Yes	Food	Probable

The scale for the HFDS level of evidence of interaction with cytochromes is available in Supplementary Table S1, available at https://doi.org/10.1016/j.esmoop.2022.100650, and has been reported in a previous study.¹³ Version 2 of the application allowed both auto-implementation and the acquisition of CYP-interacting food through a specific food questionnaire. In version 2 of the application, food–drug interactions could be detected either through the general questionnaire or the specific food questionnaire.

CYP, cytochrome P-450; HFDI, herb and food–drug interaction; HFDS, herb, food and dietary supplements.