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Signatures (left panels) and calorimetric titration isotherms (right panels) of the binding ofRBDCoV2b to the hACE2 receptor in buffer without the addition of ZnCl2 (A) and with the addition of 1 mm Zn2+ ions (B). The concentration of hACE2 was 4.5 μm and the concentration of the RBD was in the range of 33–55 μm.
