Table 1.

Differences in the hACE2 receptor binding thermodynamics between RBD of SARS‐CoV‐1 and RBD of SARS‐CoV‐2, at pH 7.4 and 25 °C.

	RBDCoV1	RBDCoV2
K dITC (nm)	145.5 ± 25.0	144.0 ± 35.3
ΔH ITC (kcal·mol−1)	−10.50 ± 0.27	−16.15 ± 0.60
N ITC	1.03 ± 0.01	0.99 ± 0.02
−T Δ S ITC (kcal·mol−1)	1.15	6.81