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. 2023 Jan 3;2023(1):CD011881. doi: 10.1002/14651858.CD011881.pub2

NCT04073628.

Study name The long‐term impact of a light intervention on sleep and cognition in mild cognitive impairment
Methods Randomised controlled trial
Participants Inclusion criteria:
  • diagnosis of amnestic mild cognitive impairment or mild Alzheimer's disease, as defined by a MoCA score 17–24 and those who fall between 0.5–4.0 and 4.5–9.0 in the Clinical Dementia Rating Scale Sum of Boxes instrument

  • sleep disturbance indicated by PSQI score > 5 on the PSQI and sleep efficiency < 80% as indicated via actigraphy

  • resides in their own home, independent living, or assisted living facilities with a carer


Exclusion criteria:
  • diagnosed with another brain disease that fully explains the dementia (extensive brain vascular disease, Parkinson's disease, dementia with Lewy bodies, traumatic brain injury, or multiple sclerosis)

  • resides in a skilled nursing facility or long‐term care

  • recent changes in psychotropics (14 days)

  • major organ failure (e.g. kidney failure)

  • uncontrolled generalised disorders such as hypertension or diabetes

  • obstructing cataracts, macular degeneration, or blindness

  • has undergone cataract surgery and received an intraocular lens coated with ultraviolet‐ and blue‐blocking filters (400–440/440–500 nm)

  • diagnosed with severe sleep apnoea; using the Sleep Apnea scale of the Sleep Disorders Questionnaire (score of 29 as a cutoff for men and 26 for women)

  • diagnosed with restless leg syndrome using the International Restless Legs Scale, (cutoff off ≥ 11 as a positive screen)

  • history of severe photosensitivity dermatitis, severe progressive retinal disease (e.g. macular degeneration), or a permanently dilated pupil (e.g. after certain types of cataract surgery)

Interventions Intervention: active lighting intervention
Control: standard light
Outcomes Sleep quality in the participant with mild cognitive impairment (PSQI); sleep quality in the carer (PSQI)
Starting date April 2020
Contact information Mariana Figueiro
Notes Estimated date of study completion: April 2024