Table 3.
Association of Worse Cough-Specific Quality of Life with Clinical Outcomes at 12 Months
| Outcome at 12 Months | Univariable Analysis |
Multivariable Analysisa |
||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P Value | Hazard Ratio (95% CI) | P Value | |
| Respiratory hospitalization | 1.105 (1.067-1.144) | < .0001b | 1.065 (1.025-1.107) | .0016b |
| Death | 1.079 (1.031-1.129) | .0011b | 1.074 (1.020-1.130) | .0060b |
| Lung transplantation | 1.139 (1.080-1.200) | < .0001b | 1.087 (1.022-1.156) | .0079b |
| Any outcome (first of those stated above) | 1.102 (1.063-1.142) | < .0001b | 1.066 (1.024-1.099) | .0021b |
| Decrease in FVC ≥ 10% from baseline | 1.004 (0.962-1.047) | .8597 | 1.032 (0.986-1.080) | .1715 |
| Decrease in Dlco ≥ 15% from baseline | 1.000 (0.881-1.135) | .9984 | 1.033 (0.907-1.175) | .6265 |
Dlco = diffusing capacity of the lungs for carbon monoxide.
a
Adjusted for baseline Dlco % predicted, baseline FVC % predicted, baseline Leicester Cough Questionnaire score, age at time of consent, presence of coronary artery disease, presence of COPD, presence of gastroesophageal reflux disease, interstitial lung disease diagnosis type, pulmonary arterial hypertension, race, sex, angiotensin-converting enzyme inhibitor use, and smoking history.
b
Denotes statistical significance for α < 0.05.