Figure 2. Disentangling proton exchange rate and concentration using CEST-MRF.
(a and d) Proton density images of L-arginine phantoms with varying concentrations (top row) and pH (bottom row) along with the associated quantitative chemical exchange rate (b and e) and L-arginine concentration (c and f) maps generated from MRF dot-product matching. The CEST-MRF reconstruction was able to correctly detect and quantify the different proton exchange rates and concentrations. Reproduced and modified with permission from Cohen et al., Magn Reson Med. 2018;80:2449-2463.59