Table 5.
Factors associated with RFS in the final multivariable Cox model
| Variables | Multivariate analysis |
|
|---|---|---|
| HR (95% CI) | p value | |
| PNI | ||
| No versus yes | 3.94 (1.077–8.027) | 0.035 |
| Tumor size, cm | ||
| <2.5 versus ≥2.5 | 3.70 (1.016–13.443) | 0.047 |
| Nodal status | ||
| Negative versus positive | 3.33 (1.479–7.747) | 0.004 |
| Grade | ||
| Low versus high | 4.87 (1.606–14.247) | 0.004 |
| Functional | ||
| Yes versus no | 1.05 (0.468–2.335) | 0.913 |
| METTL14 | ||
| Low versus high | 0.38 (0.154–0.917) | 0.032 |
| METTL16 | ||
| Low versus high | 1.51 (0.747–3.033) | 0.253 |
| ALKBH5 | ||
| Low versus high | 1.57 (0.638–3.870) | 0.326 |
| HNRNPC | ||
| Low versus high | 3.21 (1.063–9.096) | 0.039 |
| YTHDF1 | ||
| Low versus high | 1.58 (0.741–3.347) | 0.238 |
| YTHDF2 | ||
| Low versus high | 1.72 (1.034–4.653) | 0.028 |
| YTHDF3 | ||
| Low versus high | 1.53 (0.594–3.943) | 0.379 |
| Risk score | ||
| Low versus high | 33.04 (4.341–251.434) | 0.001 |
Analyses were performed using the former category of each variable as the reference. CI, confidence interval; HR, hazard ratio; PNI, perineural invasion.