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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Nitric Oxide. 2022 Nov 30;130:58–68. doi: 10.1016/j.niox.2022.11.005

Figure 2. Endothelial dysfunction excerpts cardiovascular disorders that can be alleviated by increased nitric oxide (NO) bioavailability upon photobiomodulation (PBM) with near-infrared (NIR) light.

Figure 2.

Nitric oxide (NO) is a gaseous mediator to maintain vascular homeostasis. A hallmark of endothelial dysfunction and subsequent pro-thrombotic events is endothelial NO synthase (eNOS) suppression with concomitant NO deficiency, resulting in vasoconstriction, inflammation, platelet activation, hypercoagulation, and cardiovascular diseases. Photobiomodulation (PBM) with near-infrared (NIR) light exposure has the potential to increase NO bioavailability via multiple mechanisms.