Table 4.
Monitoring laboratory variables in the study groups at baseline and end of the trial
| Variable | Intervention (n=24) | Placebo (n=27) | P-value* | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline mean (SD) | End of the trial mean (SD) | P-value | Mean difference (SEa) | Baseline | End of trial | P-value# | Mean difference ± SE | ||
| WBC | 11.54 (10.69) | 10.69 (4.90) | 0.599 | −0.85 (7.84) | 10.14 (4.53) | 11.50 (5.48) | 0.191 | 1.36 (5.24) | 0.450 |
| Hb | 10.18 (2.39) | 10.00 (2.28) | 0.635 | −0.18 (0.36) | 9.60 (1.69) | 9.42 (1.82) | 0.539 | −0.18 (0.29) | 0.660 |
| PLT | 219.54 (142.56) | 239.88 (101.49) | 0.539 | 20.34 (32.57) | 203.74 (91.10) | 256.92 (175.1) | 0.076 | 53.18 (28.76) | 0.551 |
| PT | 15.40 (5.75) | 14.43 (4.00) | 0.323 | −0.97 (0.96) | 15.30 (4.55) | 14.84 (4.46) | 0.680 | −0.45 (1.07) | 0.685 |
| PTT | 32.87 (6.98) | 32.30 (7.66) | 0.753 | −0.57 (1.78) | 46.29 (43.46) | 35.47 (12.55) | 0.222 | −10.83 (8.66) | 0.332 |
| INR | 1.44 (0.72) | 1.29 (0.44) | 0.248 | −0.14 (0.12) | 1.39 (0.54) | 1.55 (0.83) | 0.101 | 0.16 (0.10) | 0.049 |
| FBG | 141.79 (64.53) | 113.13 (56.38) | 0.072 | −28.67 (15.20) | 122.85 (59.11) | 137.11 (75.55) | 0.358 | 14.26 (15.23) | 0.128 |
| BUN | 70.58 (63.80) | 55.13 (52.60) | 0.187 | −15.46 (11.38) | 66.26 (39.18) | 61.11 (41.80) | 0.569 | −5.1 (8.93) | 0.508 |
| Cr | 1.37 (0.83) | 1.00 (0.37) | 0.028 | −0.36 (0.16) | 1.53 (0.76) | 1.69 (1.07) | 0.345 | 0.16 (0.17) | 0.005 |
| Na | 139.29 (9.59) | 136.33 (3.76) | 0.113 | −2.96 (1.79) | 137.56 (7.71) | 136.33 (4.51) | 0.428 | −1.22 (1.52) | 0.815 |
| K | 3.97 (0.48) | 3.85 (0.51) | 0.465 | −0.12 (0.16) | 3.77 (0.60) | 5.36 (7.38) | 0.272 | 1.59 (1.42) | 0.305 |
| Ca | 8.33 (0.89) | 8.56 (1.03) | 0.270 | 0.23 (0.20) | 8.59 (0.50) | 8.18 (1.06) | 0.031 | −0.4 (0.18) | 0.044 |
| Mg | 2.09 (0.34) | 2.14 (0.54) | 0.694 | 0.05 (0.13) | 2.19 (0.60) | 2.16 (0.60) | 0.882 | −0.02 (0.16) | 0.917 |
| PH | 3.30 (1.44) | 3.43 (1.06) | 0.654 | 0.14 (0.30) | 3.43 (1.15) | 3.93 (1.78) | 0.181 | 0.51 (0.37) | 0.263 |
| ALT (SGPT) | 41.42 (37.65) | 19.88 (16.34) | 0.003 | −21.54 (6.55) | 53.53 (68.13) | 49.19 (55.30) | 0.735 | −4.3 (12.67) | 0.022 |
| AST (SGOT) | 52.88 (46.50) | 31.75 (30.20) | 0.020 | −21.13 (8.46) | 55.54 (59.06) | 44.74 (29.07) | 0.349 | −10.80 (11.33) | 0.119 |
| Total bilirubin | 1.24 (0.81) | 0.87 (0.60) | 0.026 | −0.37 (0.15) | 0.63 (0.21) | 0.69 (0.49) | 0.512 | 0.06 (0.09) | 0.833 |
| Direct bilirubin | 0.57 (0.45) | 0.45 (0.35) | 0.092 | −0.12 (0.07) | 0.29 (0.13) | 0.33 (0.30) | 0.494 | 0.04 (0.06) | 0.868 |
| Lactate | 12.93 (6.28) | 8.96 (6.95) | 0.013 | −3.97 (1.48) | 10.71 (4.38) | 15.72 (6.66) | 0.001 | 5.01 (1.33) | <0.001 |
| Alb | 3.05 (0.40) | 3.71 (0.62) | <0.001 | 0.66 (0.14) | 3.12 (0.48) | 3.13 (0.66) | 0.912 | 0.01 (0.13) | 0.001 |
| Total protein | 5.11 (0.74) | 5.74 (0.69) | 0.001 | 0.63 (0.16) | 5.16 (1.07) | 5.14 (1.05) | 0.904 | −0.02 (0.15) | 0.003 |
aStandard error
#Obtained from paired T-test
*Obtained from analysis of covariance (ANCOVA), the mean values of outcomes were compared between groups, and adjustment was made for baseline values of compared outcomes