Table 1.
The expression of IGFBP2 in ovarian cancer precursor lesions and associated patient characteristics.
| Specimen | Age | Histology | p53 mutation pattern | IGFBP2 staining | ki67% | Concurrent HGSOC | Germline mutations |
| FTE-1 | 67 | p53 signature | Missense | Negative | 2 | No | |
| FTE-2 | 56 | p53 signature | Missense | Negative | NA | No | |
| FTE-3 | 46 | p53 signature | Missense | Negative | 1 | No | |
| FTE-4 | 46 | p53 signature | Missense | Negative | 1 | No | |
| FTE-5 | 46 | p53 signature | Missense | Negative | 1 | No | |
| FTE-6 | 46 | p53 signature | Missense | Negative | 0 | No | |
| FTE-7 | 73 | p53 signature | Missense | Negative | 1.2 | No | |
| FTE-8 | 73 | p53 signature | Missense | Negative | 2 | No | |
| FTE-9 | 73 | p53 signature | Missense | Negative | 1 | No | |
| FTE-10 | 58 | p53 signature | Missense | Negative | 5.3 | No | Lynch syndrome |
| FTE-11 | 70 | p53 signature | Missense | Negative | 1 | No | |
| FTE-12 | 70 | p53 signature | Missense | Negative | 2 | No | |
| FTE-13 | 72 | p53 signature | Missense | Negative | 4.3 | Yes | |
| FTE-14 | 60 | p53 signature | Missense | Negative | NA | No | |
| FTE-15 | 52 | p53 signature | Missense | Negative | 1 | No | |
| FTE-16 | 71 | Dormant/Active STIC* | Missense | Positive/positive | 7/35 | No | |
| FTE-17 | 50 | Dormant/Active STIC* | Missense | Negative/positive | 1/43 | No | |
| FTE-18 | 44 | Dormant/Active STIC* | Missense | Negative/positive (weak) | 5.2/40 | No | VUS, ATM(p.V455M), RAD50(p.R1260H) |
| FTE-19 | 65 | Dormant/Active STIC* | Nonsense | Negative/positive (weak) | NA | No | |
| FTE-20 | 46 | Dormant STIC | Missense | Negative | 2 | No | |
| FTE-21 | 47 | Dormant STIC | Missense | Negative | 4 | No | |
| FTE-22 | 46 | Dormant STIC | Missense | Negative | 6 | Yes | |
| FTE-23 | 72 | Dormant STIC | Missense | Negative | 2 | No | |
| FTE-24 | 73 | Dormant STIC | Missense | Negative | 1 | No | |
| FTE-25 | 73 | Dormant STIC | Missense | Negative | 2 | No | |
| FTE-26 | 58 | Dormant STIC | Missense | Negative | 6 | No | Lynch syndrome |
| FTE-27 | 58 | Dormant STIC | Missense | Negative | 2 | No | Lynch syndrome |
| FTE-28 | 51 | Dormant STIC | Missense | Negative | 2 | No | |
| FTE-29 | 72 | Dormant STIC | Missense | Negative | 1 | Yes | |
| FTE-30 | 55 | Dormant STIC | Missense | Negative | 1 | No | BRCA, type? |
| FTE-31 | 60 | Dormant STIC | Missense | Positive | 5 | No | |
| FTE-32 | 68 | Dormant STIC | Missense | Negative | 2 | No | |
| FTE-33 | 66 | Dormant STIC | Missense | Negative | 2 | No | |
| FTE-34 | 69 | Dormant STIC | Missense | Negative | 1 | Yes | |
| FTE-35 | 69 | Dormant STIC | Missense | Negative | 2 | Yes | |
| FTE-36 | 58 | Dormant STIC | Missense | Negative | 1 | No | |
| FTE-37 | 58 | Dormant STIC | Missense | Negative | 1 | No | |
| FTE-38 | 58 | Dormant STIC | Missense | Negative | 0 | No | |
| FTE-39 | 58 | Dormant STIC | Missense | Negative | No | ||
| FTE-40 | 73 | Dormant STIC | Missense | Negative | 3 | No | |
| FTE-41 | 73 | Dormant STIC | Missense | Negative | 2 | No | |
| FTE-42 | 73 | Dormant STIC | Missense | Negative | 3 | No | |
| FTE-43 | 46 | Active STIC | Missense | Positive | 74 | No | |
| FTE-44 | 65 | Active STIC | Missense | Positive | 95 | No | BRCA2 |
| FTE-45 | 65 | Active STIC | Missense | Positive | 96 | No | BRCA2 |
| FTE-46 | 66 | Active STIC | Missense | Positive | NA | Yes | |
| FTE-47 | 76 | Active STIC | Missense | Positive | NA | No | |
| FTE-48 | 58 | Active STIC | Nonsense | Positive (weak) | 84 | No | |
| FTE-49 | 71 | Active STIC | Missense | Positive | 12 | No | |
| FTE-50 | 71 | Active STIC | Nonsense | Positive | 53 | No | |
| FTE-51 | 71 | Active STIC | Nonsense | Positive | 55 | No | |
| FTE-52 | 56 | Active STIC | Missense | Positive (weak) | NA | No | |
| FTE-53 | 75 | Active STIC | Missense | Positive | 62 | No | |
| FTE-54 | 75 | Active STIC | Missense | Positive | 69 | No | |
| FTE-55 | 71 | Active STIC | Missense | Positive (weak) | 17 | No | BRCA1 |
| FTE-56 | 71 | Active STIC | Missense | Positive | 29 | No | |
| FTE-57 | 71 | Active STIC | Missense | Positive | 23 | No | |
| FTE-58 | 57 | Active STIC | Missense | Positive | NA | Yes | |
| FTE-59 | 63 | Active STIC | Missense | Positive | NA | Yes | |
| FTE-60 | 57 | Active STIC | Missense | Positive | 44 | Yes | |
| FTE-61 | 57 | Active STIC | Missense | Positive | 52 | Yes | |
| FTE-62 | 57 | Active STIC | Missense | Positive | 47 | Yes | |
| FTE-63 | 79 | Active STIC | Missense | Positive | 20 | No | |
| FTE-64 | 46 | Active STIC | Nonsense | Positive (weak) | 62 | No | BRCA1 |
| FTE-65 | 46 | Active STIC | Nonsense | Positive (weak) | 78 | No | BRCA1 |
| FTE-66 | 44 | Active STIC | Missense | Positive | 25 | No | VUS, ATM(p.V455M), RAD50(p.R1260H) |
| FTE-67 | 41 | Active STIC | Missense | Positive | 81 | No | BRCA2 |
| FTE-68 | 51 | Active STIC | Nonsense | Negative | 23 | No | |
| FTE-69 | 72 | Active STIC | Missense | Positive | 42 | Yes | |
| FTE-70 | 72 | Active STIC | Missense | Positive | 31 | Yes | |
| FTE-71 | 62 | Active STIC | Missense | Positive | 40 | Yes | BRCA1 |
| FTE-72 | 85 | Active STIC | Nonsense | Positive | 70 | Yes | |
| FTE-73 | 85 | Active STIC | Nonsense | Positive | 78 | Yes | |
| FTE-74 | 67 | Active STIC | Nonsense | Positive | 33 | No | |
| FTE-75 | 65 | Active STIC | Missense | Negative | 21 | No | |
| FTE-76 | 59 | Active STIC | Missense | Positive | 52 | Yes |
EEC: endometrial endometrioid carcinoma; MMMT: malignant mixed mesenchymal tumor; ESC: endometrial serous carcinoma; BCC: basal cell carcinoma; NA: not available.
*:
dormant SITC continuous with active STIC.