Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Properties of different polarized macrophages
| Phenotype | M1 | M2a | M2b | M2c |
|---|---|---|---|---|
| Inducers | LPS/IFN-γ | IL-4/13 | IC | IL-10 |
| CD86 | + + | + + + | − | + |
| HLA-DR | + + | + + + | − | + |
| CD163 | − | − | − | + + + |
| CD206 | + | + + + | − | + + |
| TNF-α | + + | − | + + | − |
| IFN-γ | + + | − | + + | − |
| IL-1β | + + | − | + + | − |
| IL-6 | + + | − | + + | − |
| IL-10 | + | + + + + | + + + + | + + + + |
| IL-12 | + + + + | − | + | − |
| IL-23 | + + | − | − | − |
| TGF-β | − | − | − | + + |
− No expression; + low expression; + + middle expression; + + + high expression
