TABLE 2.
Infectious contenta of R. australis in IFN-γ gene knockout mice subjected to adoptive transfer with immune or nonimmune CD8 T lymphocytes
Group no. | Adoptive transfer | 103 PFU of R.
australis/g of tissue from the:
|
||
---|---|---|---|---|
Spleen | Lungs | Liver | ||
1 | Immune CD8b | 29.6 ± 1.5 | 17.2 ± 3.9 | 19 ± 0.9 |
2 | Naïve CD8 | 4,814 ± 758 | 5,449 ± 282 | 2,837 ± 400 |
3 | No transfer | 2,816 ± 189 | 2,778 ± 379 | 1,996 ± 163 |
Mean of two repeated experiments, ± standard deviation.
Immune IFN-γ gene knockout CD8 T-lymphocyte recipients' organs contained significantly fewer R. australis PFU than the corresponding organs of recipients of naïve IFN-γ gene knockout CD8 T lymphocytes (P < 0.05) or those of mice with no transfer (P < 0.05).