Table 3. Formulation of diluents for prepared microspheres .
Diluent composition | 1 | 2 | ||
Compound | Amount (w/v %) | Compound | Amount (w/v %) | |
Tonicity modifier | Mannitol | 9 | Mannitol | 7.4 |
Surfactant | NaCMC | 1.4 | NaCMC | 2.6 |
Surfactant | Poloxamer 188 | 0.4 | Polysorbate 80 | 0.17 |
For both formulations, the solvent was water for injection. NaCMC; Sodium carboxymethylcellulose.