Table 4. Characterization of prepared particles. Data were presented as mean ± standard deviation (n=3) .

	Particle size (µm)	Span	EE (%)	DL (%)	Appearance
F1	23.4 ± 3.81	0.80 ± 0.05	23.4 ± 3.56	1.93 ± 0.29	A spherical, porous surface
F2	24.2 ± 6.20	0.98 ± 0.46	24.7 ± 1.70	2.03 ± 0.14	A spherical, porous surface
F3	10.0 ± 0.00	1.07 ± 0.07	52.2 ± 8.30	4.93 ± 0.68	A spherical and aggregate, slightly porous surface
F4	12.0 ± 2.54	2.67 ± 1.46	66.6 ± 6.32	5.47 ± 0.52	ND
F5	20.3 ± 0.49	1.29 ± 0.39	90.8 ± 1.07	7.45 ± 0.09	A spherical, porous surface
F6	6.65 ± 0.49	1.20 ± 0.56	36.5 ± 0.03	3.00 ± 0.00	A spherical and slightly aggregate, smooth surface
F7	21.9 ± 2.80	1.15 ± 0.01	50.8 ± 7.75	7.12 ± 1.09	A spherical, porous surface
F8	8.77 ± 0.49	1.70 ± 0.42	46.2 ± 9.19	6.48 ± 1.29	ND
F9*	6.55 ± 0.35	1.91 ± 0.45	52.1 ± 3.67	7.29 ± 0.51	A spherical, slight porous surface
F10	10.7 ± 1.54	1.80 ± 0.37	50.1 ± 4.61	7.02 ± 0.65	ND
F11	27.0 ± 7.77	1.17 ± 0.69	30.5 ± 3.25	5.06 ± 0.54	Both spherical and Irregular, smooth surface
F12	48.9 ± 1.55	2.07 ± 0.11	30.5 ± 1.11	4.66 ± 0.39	Irregular and aggregate, smooth surface
F13	22.5 ± 0.14	0.85 ± 0.96	22.4 ± 2.54	3.13 ± 0.35	ND
F14	27.2 ± 7.63	0.77 ± 0.01	42.8 ± 1.09	6.00 ± 0.15	ND
F15	17.7 ± 5.28	1.50 ± 0.04	20.4 ± 1.96	2.86 ± 0.27	ND
F16	17.1 ± 4.38	1.41 ± 0.01	21.0 ± 0.69	2.95 ± 0.09	A spherical, smooth surface
F17	37.6 ± 1.53	0.88 ± 0.40	49.5 ± 4.06	6.93 ± 0.56	A spherical, smooth surface
F18	47.7 ± 3.18	1.18 ± 0.41	31.4 ± 1.46	4.39 ± 0.20	ND
F19	22.2 ± 2.99	1.18 ± 0.44	58.7 ± 4.54	4.81 ± 0.37	A fine spherical, smooth surface
F20	10.6 ± 0.94	1.25 ± 0.35	31.1 ± 0.87	2.55 ± 0.07	ND

*Optimized formulation. ND; Not determined, EE; Encapsulation efficiency, DL; Drug loading.