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. Author manuscript; available in PMC: 2023 Jan 3.
Published in final edited form as: Neurobiol Dis. 2022 Jul 9;172:105816. doi: 10.1016/j.nbd.2022.105816

Fig. 4.

Fig. 4.

Prevention of oAβ-impaired mf-LTP by activation of cGMP-PKG signaling pathway. (A) Schematic diagram of presynaptic the cAMP-PKA and cGMP-PKG signaling pathways and the effects of different antagonists. (B) sildenafil, a specific PDE5 inhibitor prevented the inhibition of LTP by AD but the rescued LTP was blocked by applying PKG inhibitors Rp-8-Br-cGMPS (10 μM) (AD: 120.4 ± 4.56% n = 4 vs AD with 50 nM sildenafil: 163.5 ± 5.29% n = 4, p = 0.02; AD with 50 nM sildenafil: 163.5 ± 5.29% n = 4 vs. AD with 50 nM sildenafil and 10 μM Rp-8-Br-cGMPS: 113.1 ± 8.76% n = 8, p = 0.0026; one way ANOVA test). * p < 0.05, **p < 0.01.