. Author manuscript; available in PMC: 2023 Feb 22.

Published in final edited form as: Anal Chem. 2022 Feb 10;94(7):3091–3102. doi: 10.1021/acs.analchem.1c04140

Table 5.

Comparison between PNC_direct and Derived PNC_mean and PNC_distribution Based on the Combination of In-House Au Mass Fraction with the Mean Particle Size or PSD Simultaneously Obtained in This Study by spICP-MS for Different Commercial AuNPs^a

	central tendency (PNC_mean^b	full PSD (PNC_distribution)
30 nm PVP	106.5 ± 7.0 (14.1)^c	92.6 ± 6.4 (12.9)^c
30 nm bPEI	102.8 ± 10.8 (21.8)^c	90.9 ± 9.8 (19.6)^c
30 nm PEG	114.7 ± 8.2 (16.4)^c	93.4 ± 7.0 (13.9)^c
60 nm PVP	102.1 ± 7.4 (14.7)^c	83.1 ± 6.1 (12.3)^c
60 nm bPEI first lot	92.8 ± 10.5 (20.9)^c	77.3 ± 8.6 (17.2)^c
60 nm bPEI second lot	97.4 ± 5.7 (11.4)^c	83.3 ± 4.9 (9.8)^c
60 nm PEG first lot	87.5 ± 2.4 (4.9)^c	80.9 ± 2.3 (4.6)^c
60 nm PEG second lot	103.7 ± 9.1 (18.3)^c	92.2 ± 8.0 (16.0)^c
100 nm Citrate	92.0 ± 7.9 (15.8)^c	77.1 ± 6.6 (13.2)^c
100 nm PVP	96.2 ± 8.1 (16.2)^c	84.0 ± 7.1 (14.2)^c
100 nm bPEI	101.5 ± 9.7 (19.5)^c	91.4 ± 8.7 (17.3)^c
100 nm PEG	107.4 ± 10.1 (20.1)^c	92.4 ± 8.5 (17.1)^c

Values indicate the ratio between PNC_direct and derived PNCs, expressed in percentage, and the combined standard uncertainty (u_c) associated.

Assumes all analyte is present as spherical NPs of the central tendency diameter.

All recognized and evaluated sources of bias affecting PNC determinations were included in the parenthetical expanded uncertainty computation that corresponds to U95% C.I.