Figure 2.

Neutrophils and monocytes of PLHIV have increased complexity and reactivity compared with people without HIV in Sysmex hemocytometry. N = 1895 PLHIV with suppressed viral loads were compared to N = 15,803 people without HIV. To place treated HIV in a context, PLHIV were displayed next to acute infectious disease cohorts. These other cohorts consisted of patients presenting with acute febrile disease at the ER who subsequently underwent extensive diagnostic testing. Cohen’s d is a measure of the effect size. Differences were considered significant if P < 0.05 and relevant if Cohen d effect size was > 0.5 (A-C) Neutrophils of PLHIV were higher in complexity and reactivity than people without HIV. (D-F) Monocytes of PLHIV were higher in complexity and reactivity but lower in size. (G-I) Lymphocytes of PLHIV were greater in complexity, smaller in size and similar in reactivity.