Table 2.
Clinical Trials with CAR T-cells in AML patients as of October 7th 2022.
| Trial # | NCT# | Enrollment Status | Adoptive Cell Therapy | Phase | Recruiting Sample Size (# of patients) | Target(s) |
|---|---|---|---|---|---|---|
| 1 | NCT04796441 | Recruiting | γδT | NA | 20 | CD19 |
| 2 | NCT05388305 | Recruiting | γδT | NA | 30 | CD123 |
| 3 | NCT04766840 | Not yet recruiting | T | 1 | 9 | IM73 |
| 4 | NCT05463640 | Not yet recruiting | T | 1 | 20 | ADGRE2 |
| 5 | NCT05467254 | Not yet recruiting | T | 1 | 20 | CD33, CLL1 |
| 6 | NCT05473221 | Not yet recruiting | T | 1 | 20 | CD33 |
| 7 | NCT05467202 | Not yet recruiting | T | 1 | 20 | CLL1 |
| 8 | NCT04803929 | Recruiting | T | Early 1 | 25 | ILT3 |
| 9 | NCT03631576 | Unknown | T | 2,3 | 20 | CD123, CLL1 |
| 10 | NCT04010877 | Recruiting | T | 1, 2 | 10 | CLL1 + CD123 and/or CD33 |
| 11 | NCT04169022 | Recruiting | T | NA | 50 | IL1RAP |
| 12 | NCT04219163 | Recruiting | T | 1 | 18 | CLL1 |
| 13 | NCT05023707 | Recruiting | T | 1,2 | 5 | FLT3 |
| 14 | NCT05252572 | Recruiting | T | Early 1 | 36 | CLL1 |
| 15 | NCT05239689 | Recruiting | T | Early 1 | 36 | CD38 |
| 16 | NCT05488132 | Recruiting | T | 1,2 | 20 | Siglec-6 |
| 17 | NCT03796390 | Unknown | T | 1 | 15 | CD123 |
| 18 | NCT04257175 | Recruiting | T | 2,3 | 10 | CD19 |
| 19 | NCT03585517 | Unknown | T | 1 | 15 | CD123 |
| 20 | NCT03222674 | Unknown | T | 1,2 | 10 | Muc1, CLL1, CD33, CD38, CD56, CD123 |
| 21 | NCT05248685 | Recruiting | T | 1 | 20 | CD33, CLL1 |
| 22 | NCT04658004 | Not yet recruiting | T | Early 1 | 36 | NKG2D |
| 23 | NCT04884984 | Recruiting | T | 1,2 | 20 | CLL1 |
| 24 | NCT04599543 | Not yet recruiting | T | Early 1 | 36 | CD123 |
| 25 | NCT03473457 | Terminated | T | NA | 2 | Muc1, CD34, CD133, CD117, CD123, CD56, CD33, CD38 |
| 26 | NCT02944162 | Unknown | NK | 1, 2 | 10 | CD33 |
| 27 | NCT05266950 | Recruiting | T | 1 | 7 | CI-135 |
| 28 | NCT03114670 | Unknown | T | 1 | 20 | CD123 |
| 29 | NCT05445011 | Recruiting | T | 1 | 12 | FLT3 |
| 30 | NCT05215015 | Recruiting | NK | Early 1 | 18 | CD33, CLL1 |
| 31 | NCT04623944 | Recruiting | NK | 1 | 90 | NKG2D |
| 32 | NCT04097301 | Terminated | T | 1, 2 | 8 | CD44v6 |
| 33 | NCT05445765 | Not yet recruiting | T | 1 | 10 | CD33 |
| 34 | NCT03126864 | Terminated | T | 1 | 11 | CD33 |
| 35 | NCT03904069 | Not yet recruiting | T | 1 | 40 | FLT3 |
| 36 | NCT04835519 | Recruiting | T | 1,2 | 25 | CD33 |
| 37 | NCT04014881 | Unknown | T | 1 | 50 | CD123 |
| 38 | NCT04692948 | Recruiting | T | NA | 5 | CD276 |
| 39 | NCT03556982 | Unknown | T | 1,2 | 10 | CD123 |
| 40 | NCT04351022 | Recruiting | T | 1,2 | 20 | CD38 |
| 41 | NCT04318678 | Recruiting | T | 1 | 32 | CD123 |
| 42 | NCT05017883 | Recruiting | T | NA | 5 | FLT3 |
| 43 | NCT05432401 | Recruiting | T | Early 1 | 18 | FLT3 |
| 44 | NCT04789408 | Recruiting | T | 1 | 40 | CLL1 |
| 45 | NCT05247957 | Recruiting | NK | 1 | 9 | NKG2D |
| 46 | NCT03971799 | Recruiting | T | 1,2 | 37 | CD33 |
| 47 | NCT02623582 | Terminated | T | Early 1 | 7 | CD123 |
| 48 | NCT04272125 | Recruiting | T | 1,2 | 40 | CD123 |
| 49 | NCT03612739 | Withdrawn | T | 1 | 0 | NKR-2 |
| 50 | NCT04923919 | Recruiting | T | Early 1 | 100 | CLL1 |
| 51 | NCT02799680 | Unknown | T | 1 | 12 | CD33 |
| 52 | NCT04265963 | Recruiting | T | 1,2 | 45 | CD123 |
| 53 | NCT05008575 | Recruiting | NK | 1 | 27 | CD33 |
| 54 | NCT01864902 | Unknown | T | 1,2 | 10 | CD33 |
| 55 | NCT05105152 | Recruiting | T | 1 | 18 | CD33 |
| 56 | NCT05016063 | Not yet recruiting | T | Early 1 | 32 | CLL1 |
| 57 | NCT02203825 | Completed | T | 1 | 12 | NKG2D |
| 58 | NCT03896854 | Recruiting | T | 1,2 | 15 | CD19 |
| 59 | NCT03291444 | Recruiting | T | 1 | 30 | Muc1, CD34, CD123, CD117, CD56, CD38, CD33 |
| 60 | NCT02159495 | Active, not recruiting | T | 1 | 31 | CD123 |
| 61 | NCT05092451 | Not yet recruiting | NK | 1, 2 | 94 | CD70 |
| 62 | NCT03885076 | Unknown | γδT | N/A | 20 | CD33 |
| 63 | NCT05457010 | Not yet recruiting | T | 1 | 24 | CD123 |
| 64 | NCT04106076 | Withdrawn | T | 1 | 0 | CD123 |
| 65 | NCT03190278 | Recruiting | T | 1 | 65 | CD123 |
| 66 | NCT04662294 | Recruiting | T | Early 1 | 108 | CD70 |
| 67 | NCT03927261 | Recruiting | T | 1 | 88 | CD33 |
| 68 | NCT05442580 | Not yet recruiting | T | 1 | 36 | CD38 |
| 69 | NCT04230265 | Recruiting | T | 1 | 45 | CD123 |
| 70 | NCT04762485 | Recruiting | T | 1,2 | 20 | CD7 |
| 71 | NCT04033302 | Recruiting | T | 1,2 | 30 | CD7 |
| 72 | NCT05513612 | Recruiting | T | 1 | 20 | CD19, BCMA, CD123, CD7 |
| 73 | NCT01716364 | Not yet recruiting | T | 1 | 6 | Lewis Y |
| 74 | NCT05454241 | Not yet recruiting | T | 2 | 22 | CD7 |
| 75 | NCT03672851 | Terminated | T | 1 | 2 | CD123 |
| 76 | NCT03018405 | Unknown | T | 1,2 | 146 | NKR-2 |
| 77 | NCT03766126 | Active, not recruiting | T | 1 | 12 | CD123 |
| 78 | NCT04678336 | Recruiting | T | 1 | 12 | CD123 |
| 79 | NCT02742727 | Unknown | NK | 1,2 | 10 | CD7 |
| 80 | NCT04167696 | Recruiting | T | 1 | 27 | NKG2D |
| 81 | NCT05377827 | Not yet recruiting | T | 1 | 48 | CD7 |
| 82 | NCT04156256 | Unknown | T | Early 1 | 20 | CD33, CD123 |
| 83 | NCT03795779 | Recruiting | T | Early 1 | 20 | CD33, CLL1 |
| 84 | NCT05518357 | Recruiting | T | Phase 1 | 15 | ILT3 |
Summary of CAR T-cell AML therapies published on clinicaltrials.gov by enrollment status, phase, recruitment size, and target selection as per October 7th 2022.