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. 2022 Feb 18;24(6):666–670. doi: 10.4103/aja202199

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Copyright: ©The Author(s)(2022)

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The expressions of SIRT1, p53, and FOXO3a in penile tissues. The expression of (a) SIRT1, (b) p53, and (c) FOXO3a in penile tissues was detected by western blot analysis. SIRT1 expression was significantly elevated in the Res treatment group, while FOXO3a and p53 expression declined. The expression trend was enhanced by Tad addition. In contrast, NAM treatment resulted in the opposite expression profile. ^*P < 0.05, ^**P < 0.01, and ^***P < 0.001. Cont: control group, the control rats were administered intragastric normal saline; NAM: niacinamide group, rats in the NAM group were administered niacinamide intragastrically; Res: resveratrol group, rats in the Res group were administered resveratrol intragastrically; Res+Tad: resveratrol and tadalafil group, rats in the Res+Tad group received daily intragastric resveratrol and tadalafil. NS: no significant difference; SIRT1: silent information regulator 2-related enzyme 1; FOXO3a: forkhead box O3; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.