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. 2023 Jan 3;3:2. doi: 10.1038/s43856-022-00232-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Linear mixed effects model (LMM) used to test differences between day 3 and baseline (day 1), day 14 and day 3, and day 14 and baseline between remdesivir (RDV)- and placebo-treated patients. a Longitudinal plots of biomarker absolute value changes (mean with standard error) in RDV- (yellow) vs. placebo-treated (blue) patients. Dashed lines indicate normal ranges or expected values in healthy individuals. b Longitudinal plots of fold change (mean with standard error) in biomarkers in RDV- (yellow) vs placebo-treated (blue) patients. *FDR < 0.05, **FDR < 0.01, ***FDR < 0.001, ****FDR < 0.0001. Significance is determined by the LMM. The number of patients used in the LMM for each biomarker is provided Supplementary Data 1.