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. Author manuscript; available in PMC: 2023 Jan 3.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2022 Mar 14;19(7):451–467. doi: 10.1038/s41575-022-00591-0

Figure 2 ∣. PMC-MDSC induction during spasmolytic polypeptide-expressing metaplasia (SPEM) development.

Figure 2 ∣

Acutely, Slfn4+ myeloid-derived suppressor cells (MDSCs) regulated by Shh signalling track to the stomach, but do not develop their T-cell suppressor function until levels of tissue IFNα produced by plasmacytoid dendritic cells (pDCs) increase. SPEM development coincides with maximal expression of Slfn4 and the Slfn4+ MDSCs acquire T-cell suppressor function 118,125. Slfn4+-MDSCs express NFκB and secrete regulatory microRNAs such as MIR130b203. DAMPs, damage-activated molecular patterns.