FIG. 3.

Effect of in vivo administration of anticytokine MAbs on host resistance against L. monocytogenes infection in OVA-immunized mice. Mice were injected with anti–IL-4 MAb (A), anti–IL-10 MAb (B), or anti–IFN-γ MAb (C) on day 28 of immunization. Control mice were injected with normal rat globulin instead of anticytokine MAbs. Mice were infected with 2 × 10³ CFU of viable L. monocytogenes cells 1 h later, and the numbers of bacteria in the spleens and livers of these animals were determined on day 5 of infection. Each result represents the mean and SD for a group of four mice. An asterisk indicates a significant difference from the result for the normal rat globulin-treated group at a P value of <0.01. The results were reproduced in three repeat experiments.