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. 2022 Dec 27;15(1):2157697. doi: 10.1080/19490976.2022.2157697

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Cohort construction and microbiota characteristics of three IBS subtypes. (a) Conceptual outline of cohort construction and classification; (b) Principal Coordinates Analysis of gut microbiota composition of patients with different IBS subtypes by Bray-Curtis dissimilarities, the difference among IBS subtypes was assess by PERMANOVA test. (c) Diversity (Shannon Index) and richness of gut microbiota of IBS patients and non-IBS controls in different subtypes, * p < .05, ** p < .01, *** p < .001, **** p < .0001; (d) Principal Coordinates Analysis of gut microbiota composition of patients with different IBS subtypes and corresponding non-IBS controls by Bray-Curtis dissimilarities, the difference among IBS subtypes was assess by PERMANOVA test.