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. 2022 Dec 27;15(1):2157697. doi: 10.1080/19490976.2022.2157697

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Compositional and functional alterations in gut microbiota of patients with different IBS subtypes. (a) The alterations of six phyla in different IBS subtypes by comparing to corresponding non-IBS control; (b) The alterations of 37 genera in different IBS subtypes by comparing to corresponding non-IBS control; (c) 64 microbial genera that only altered in one specific IBS subtype. The alteration was assessed by comparing IBS cohort and non-IBS cohort for each subtype using the linear discriminative analysis (LDA) effect size biomarker discovery tool (p < .05, LDA >2, FDR<0.1). (d) Volcano plots demonstrating bacterial MetaCyc pathway alterations in IBS-D, IBS-U and IBS-C; A binomial test was used to calculate the p values for the up-regulation or down-regulation of MetaCyc pathway in the IBS cohort versus the non-IBS cohort for each subtype. Colored dot indicate pathway with FDR- adjusted p < .05.