Figure 7.

M. tb uses its virulence effector proteins to inhibit autophagy. The M. tb proteins inhibit host-induced autophagy for its efficient intracellular survival inside macrophages. These proteins exhibit divergent mechanisms for the inhibition of autophagy. M. tb utilizes its effectors to dampen autophagy by inhibiting phagophore maturation, autophagosome fusion to the lysosome, and autolysosome acidification. The efficient mechanisms utilized by M. tb culminate in the reduction of autophagy flux. Exploring the interaction between these proteins will shed light on a better understanding of mechanisms of autophagy inhibition by M. tb.