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. Author manuscript; available in PMC: 2023 Jan 3.
Published in final edited form as: J Neurosci Res. 2020 Aug 8;100(1):339–352. doi: 10.1002/jnr.24627

FIGURE 2.

FIGURE 2

Nal-cNP treatment significantly reduces morphine-induced thermal antinociception in the hotplate test. (a) Morphine (10 mg/kg) was administered 15 min prior to mice receiving free naloxone (8 mg/kg), Nal-cNP (Low), or cNP-empty treatment (n = 6/group). 15 min after treatment, nocifensive behaviors were observed (forepaw licking, forepaw/hindpaw withdrawal, jumping) in the hotplate test. (b) Data from the hotplate test are expressed as the percentage maximum possible effect (%MPE). Bonferroni post hoc tests revealed a significant decrease in % MPE of morphine in mice treated with Nal-cNP and free naloxone compared to cNP-empty (**p < 0.01). There were no significant differences between Nal-cNP and free naloxone treatment (p > 0.9999)