Table 2.

Linear Mixed-Effect Models of Weight Changes Over A 2-Year Follow-up

Weight Change Over 2-Year Follow-upa
Predictors	Estimatesb	CI	P
Time [Control High]c	0.67	0.57 to 0.77	<.001
Control Medium * Timed	−0.12	−0.24 to −0.00	.045
Control Low * Timee	−0.41	−0.56 to −0.25	<.001
Switch High-to-Medium * Time	−0.71	−0.87 to −0.55	<.001
Switch High-to-Low * Time	−1.10	−1.26 to −0.94	<.001
Switch Medium-to-Low * Time	−0.53	−0.68 to −0.39	<.001
Switch High-to-High * Time	−0.14	−0.51 to 0.24	.47
Switch Medium-to-Medium * Time	−0.56	−0.76 to −0.36	<.001
Switch Low-to-Low * Time	−0.77	−0.98 to −0.55	<.001
N Patients			432
N Observations			5348

Note: CI: confidence interval; P, P-value (significant values in bold); N: number.

Note: Information follows.

^aLinear mixed-effect model adjusted by sex, age, medical environment, and baseline weight.

^bEstimates indicate the mean weight change size per month.

^cReference group. Time is expressed in months. Weight change for patients switching from high-to-low risk is −0.43% (ie, 0.67%–1.10%) for each additional month, whereas for patients switching from high-to-medium risk weight change is −0.04% (ie, 0.67%–0.71%) for each additional month. No significant difference was found between controls taking high-risk drugs and patients switching within the high-risk category. Medium- and low-risk controls gained 0.55% (ie, 0.67–0.12) and 0.26% (ie, 0.67–0.41) in weight for each additional month.

^dSwitching medium-to-low and medium-to-medium showed -0.41% [(−0.53%) − (−0.12%)] and−0.44% [(−0.56%) − (−0.12%)] weight change compared to controls taking medium-risk drugs.

^eSwitching low-to-low drugs showed −0.36% [(−0.77%) − (−0.41%)] weight change compared to controls taking low-risk drugs.