Table 3.

Test of Linear Hypotheses^a

Tested Hypothesesb,c,d	Estimatese	P
Control High vs. average of Switch High-to-Low, -Medium, and -Highb	1.32	<.001
Control Medium vs average of Switch Medium-to-Low and -Mediumb	0.42	<.001
Control Low vs Switch Low-to-Lowb	0.36	.003
Switch High-to-High vs. average Switch High-to-Medium and -Lowc	0.77	<.001
Switch Medium-to-Medium vs Switch Medium-to-Lowc	−0.02	≈1
Switch High-to-Medium vs Switch High-to-Lowd	0.39	<.001

Note: P, P-value (significant values in bold).

Note: Information follows.

^aInteractions of time with both switch and control categories shown in Table 2 are tested using the matrix of contrasts.

^bHypothesis: after switch, mean weight change over time of controls equals weight change over time of patients switching from a molecule within the same risk category of controls.

^cHypothesis: after switch, mean weight change over time of patients switching within the same category of risk equals weight change over time of patients switching to a lower-risk molecule.

^dHypothesis: after switch, mean weight change over time of patients switching high-to-low equals weight change over time of patients switching high-to-medium.

^eControls taking high-risk drugs gained +1.32% more weight for each additional month than patients switching from a high-risk drug. Moreover, patients switching high-to-high gained +0.77% more weight for each additional month than the other switch groups starting with a high-risk molecule, and patients switching high-to-medium gained +0.39% more weight for each additional month than patients switching high-to-low.