Fig. 4.

Relationship between symptom improvement and the personalized atrophy network. The positive and negative syndrome scale (PANSS) score was significantly improved after active rTMS, but not the sham condition (A). All patients received repetitive transcranial magnetic stimulation at the same anatomical site, but the connectivity between the target and personalized atrophy map varied among individuals. The connectivity strength was significantly associated with the improvement of the PANSS score in the active group but not the sham group (B). The brain map (C) shows 3 representative conditions from the active group (targets are marked by white circles). The t-maps are the results of one-sample t-tests on 652 seed-to-whole brain connectivity maps using patient-specific atrophy maps as the seed.