Table 3 –

Cox proportional hazards models evaluating association of fat measures with time to Gleason grade group progression.

	Frequency		Base modela			Clinical Modelb
	Number of events	N	HR	95%CI	P-value	HR	95%CI	P-value
Volumetric Per-Peri-Prostatic Fat Measure (Tertile)
Lowest	10	59	Reference			Reference
Middle	16	58	1.73	0.78–3.82	0.17	1.81	0.82	4.00
Highest	24	58	2.72	1.29–5.73	0.01	2.63	1.23–5.60	0.01
p-value for trend					0.01			0.01
Linear Peri-Prostatic Fat Measure (Tertile)
Lowest	9	57	Reference			Reference
Middle	22	57	2.78	1.27–6.07	0.01	2.71	1.23–5.95	0.01
Highest	18	57	2.51	1.12–5.62	0.03	2.30	1.01–5.22	0.05
p-value for trend					0.47			0.37
Subcutaneous Fat Measure (Tertile)
Lowest	16	59	Reference			Reference
Middle	15	58	0.66	0.33–1.33	0.25	0.82	0.39–1.71	0.59
Highest	19	58	0.83	0.43–1.59	0.57	1.01	0.51–2.02	0.97
p-value for trend					0.24			0.19

^a– base model includes adjustment for age, only.

^b– clinical model includes adjustment for PSA, summation tumor length (please see text for description and age