Table 2.
Genome-wide significant SNPs on meta-analysis of the oral corticosteroid burst ICS response outcome in asthmatics in GERA, MGB Biobank and Rotterdam Study
| rsID | Chr | Nearest gene | Nearest coding gene | Minor allele | Major allele | Minor allele frequency | Discovery |
Replication |
Global meta-analysis p value | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GERA HR (n=5710) | GERA p value | MGB biobank HR (n=676) | Rotterdam study HR (n=465) | Replication meta-analysis p value | ||||||||
| rs138717703 | 6 | RBMXP1 | PTCHD4 | G | C | 0.01 | 1.73 (1.39–2.16) | 7.91×10−7 | 1.48 (0.75–2.90) | 3.34 (1.86–6.03) | 5.78×10−4 | 3.09×10−9 |
|
| ||||||||||||
| rs77506063 | 6 | RBMXP1 | PTCHD4 | C | T | 0.01 | 1.73 (1.39–2.16) | 7.91×10−7 | 1.48 (0.75–2.90) | 3.34 (1.86–6.03) | 5.78×10−4 | 3.09×10−9 |
|
| ||||||||||||
| rs116023293 | 6 | HNRNPA3P4 | PTCHD4 | G | A | 0.01 | 1.74 (1.40–2.16) | 5.28×10−7 | 1.27 (0.66–2.42) | 3.19 (1.73–5.90) | 3.56×10−3 | 7.65×10−9 |
|
| ||||||||||||
| rs145325916 | 6 | RBMXP1 | PTCHD4 | C | T | 0.01 | 1.74 (1.40–2.16) | 6.18×10−7 | 1.27 (0.66–2.42) | 3.19 (1.73–5.90) | 3.56×10−3 | 9.00×10−9 |
GERA, Genetic Epidemiology Research on Adult and Aging; ICS, inhaled corticosteroid; MGB, Mass General Brigham; SNPs, single-nucleotide polymorphisms.