TABLE 2.
Physical activity and risk of Alzheimer’s disease and related dementias
| Men |
Women |
||||
|---|---|---|---|---|---|
| Cases | HR (95% CI)a | Cases | HR (95% CI)a | P-heterogeneity by sex | |
| Moderate/vigorous activity | |||||
| <2.5 hours/week | 1078 | 1.00 (ref) | 1482 | 1.00 (ref) | |
| 2.5 to <5 hours/week | 1015 | 0.96 (0.88–1.05) | 1863 | 0.96 (0.89–1.03) | |
| 5 to <7 hours/week | 935 | 0.83 (0.75–0.90) | 1517 | 0.88 (0.82–0.95) | |
| 7 to <14 hours/week | 1223 | 0.88 (0.81–0.96) | 1336 | 0.89 (0.83–0.96) | |
| ≥14 hours/week | 1195 | 0.83 (0.76–0.90) | 1395 | 0.88 (0.81–0.95) | |
| P-trend | <0.001 | 0.004 | 0.52 | ||
| Moderate activity | |||||
| ≤1 hour/week | 1431 | 1.00 (ref) | 1556 | 1.00 (ref) | |
| 2–3 hours/week | 1384 | 0.96 (0.89–1.03) | 2097 | 0.96 (0.90–1.03) | |
| 4–6 hours/week | 1037 | 0.82 (0.75–0.89) | 1639 | 0.90 (0.84–0.97) | |
| 7–10 hours/week | 689 | 0.90 (0.82–0.99) | 970 | 0.90 (0.83–0.98) | |
| ≥11 hours/week | 879 | 0.84 (0.77–0.92) | 1299 | 0.89 (0.83–0.96) | |
| P-trend | <0.001 | 0.02 | 0.09 | ||
| Vigorous sports activity | |||||
| Never | 3475 | 1.00 (ref) | 5682 | 1.00 (ref) | |
| 0.5–1 hour/week | 916 | 1.00 (0.93–1.08) | 924 | 1.01 (0.94–1.08) | |
| 2–3 hours/week | 491 | 1.03 (0.94–1.14) | 451 | 0.86 (0.78–0.95) | |
| ≥4 hours/week | 472 | 0.96 (0.87–1.06) | 340 | 0.95 (0.85–1.06) | |
| P-trend | 0.60 | 0.03 | 0.12 | ||
| Vigorous work activity | |||||
| Never | 2702 | 1.00 (ref) | 6014 | 1.00 (ref) | |
| 0.5–1 hour/week | 1189 | 0.92 (0.86–0.99) | 781 | 0.94 (0.87–1.01) | |
| 2–3 hours/week | 702 | 1.01 (0.93–1.10) | 323 | 1.09 (0.97–1.22) | |
| ≥4 hours/week | 720 | 0.94 (0.87–1.03) | 197 | 0.99 (0.86–1.15) | |
| P-trend | 0.36 | 0.86 | 0.71 | ||
a
Adjusted for age at cohort entry, age at Medicare surveillance start, race/ethnicity, education, history of hypertension, history of heart disease, history of stroke, history of diabetes, Medicare usage (in-patient and out-patient claims separately, number per year), marital status, smoking status, pack-years of cigarette smoking, body mass index, total sitting hours, alcohol consumption, and Healthy Eating Index-2015.