TABLE 5.
Moderate or vigorous physical activity and risk of Alzheimer’s disease and related dementias by sitting time
| Moderate/vigorous Activity | Total sitting hours (hours/day) |
P-heterogeneity by sitting time | |||||
|---|---|---|---|---|---|---|---|
| ≤6 |
>6 to <10 |
≥10 |
|||||
| Cases | HR (95% CI)a | Cases | HR (95% CI)a | Cases | HR (95% CI)a | ||
| <2.5 hours/week | 1297 | 1.00 (ref) | 684 | 1.00 (ref) | 579 | 1.00 (ref) | |
| 2.5 to <5 hours/week | 1191 | 0.96 (0.89–1.04) | 965 | 1.00 (0.90–1.10) | 722 | 0.92 (0.82–1.03) | |
| 5 to <7 hours/week | 863 | 0.83 (0.76–0.91) | 919 | 0.93 (0.84–1.03) | 670 | 0.82 (0.73–0.92) | |
| 7 to <14 hours/week | 876 | 0.84 (0.77–0.92) | 970 | 0.95 (0.86–1.05) | 713 | 0.90 (0.80–1.01) | |
| ≥14 hours/week | 989 | 0.79 (0.73–0.87) | 1035 | 0.90 (0.81–0.99) | 566 | 0.92 (0.82–1.04) | |
| P-trend | <0.001 | 0.04 | 0.81 | 0.04 | |||
a
Adjusted for age at cohort entry, age at Medicare surveillance start, sex, race/ethnicity, education, history of hypertension, history of heart disease, history of stroke, history of diabetes, Medicare usage (in-patient and out-patient claims separately, number per year), marital status, smoking status, pack-years of cigarette smoking, body mass index, alcohol consumption and Healthy Eating Index-2015.