TABLE 6.
Moderate or vigorous physical activity and risk of Alzheimer’s disease and related dementias by no. of APOE e4
| Moderate/vigorous activity | All with APOE genotype data |
No. of APOE e4 |
P- heterogeneity by APOE | ||||
|---|---|---|---|---|---|---|---|
| 0 |
1, 2 |
||||||
| Cases | HR (95% CI)a | Cases | HR (95% CI)a | Cases | HR (95% CI)a | ||
| <2.5 hours/week | 350 | 1.00 (ref) | 243 | 1.00 (ref) | 107 | 1.00 (ref) | |
| 2.5 to <5 hours/week | 431 | 0.97 (0.84–1.12) | 262 | 0.87 (0.73–1.04) | 169 | 1.14 (0.89–1.46) | |
| 5 to <7 hours/week | 352 | 0.81 (0.69–0.94) | 230 | 0.75 (0.62–0.90) | 122 | 0.91 (0.69–1.19) | |
| 7 to <14 hours/week | 422 | 0.91 (0.79–1.06) | 255 | 0.79 (0.66–0.95) | 167 | 1.13 (0.88–1.45) | |
| ≥14 hours/week | 418 | 0.86 (0.74–1.00) | 264 | 0.76 (0.64–0.92) | 154 | 1.04 (0.80–1.35) | |
| P-trend | 0.23 | 0.07 | 0.69 | 0.02 | |||
a
Adjusted for age at cohort entry, age at Medicare surveillance start, sex, race/ethnicity, education, history of hypertension, history of heart disease, history of stroke, history of diabetes, Medicare usage (in-patient and out-patient claims separately, number per year), marital status, smoking status, pack-years of cigarette smoking, body mass index, total sitting hours, alcohol consumption, and Healthy Eating Index-2015.