Table 3.
Univariate logistic analysis of overall early death and cancer-specific early death in patients with mCRC.
| Overall early death | Cancer-specific early death | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |
| Age | ||||||
| ≤ 58 | Ref | Ref | ||||
| 59–77 | 2.07 | 1.93–2.21 | <0.001 | 1.97 | 1.84–2.12 | <0.001 |
| >77 | 4.18 | 3.86–4.53 | <0.001 | 3.8 | 3.5–4.12 | <0.001 |
| Sex | ||||||
| Male | Ref | Ref | ||||
| Female | 1.02 | 0.94–1.1 | 0.671 | 1.01 | 0.94–1.1 | 0.741 |
| Marital status | ||||||
| Married | Ref | Ref | ||||
| Unmarried | 0.86 | 0.78–0.94 | 0.001 | 0.85 | 0.77–0.94 | 0.001 |
| Unknown | 1.53 | 0.87–2.69 | 0.137 | 1.22 | 0.67–2.21 | 0.51 |
| Race | ||||||
| White | Ref | Ref | ||||
| Black | 1.08 | 1.03–1.14 | 0.004 | 1.1 | 1.04–1.16 | 0.001 |
| Other | 1.56 | 1.47–1.65 | <0.001 | 1.52 | 1.43–1.61 | <0.001 |
| Unknown | 1.52 | 1.35–1.71 | <0.001 | 1.42 | 1.26–1.61 | <0.001 |
| Median household income | ||||||
| <$40,000 | Ref | Ref | ||||
| $40,000–$54,999 | 1.04 | 0.92–1.17 | 0.568 | 1.05 | 0.93–1.19 | 0.427 |
| $55,000–$69,999 | 0.96 | 0.86–1.08 | 0.544 | 0.97 | 0.86–1.09 | 0.588 |
| >$70,000 | 0.93 | 0.83–1.05 | 0.248 | 0.92 | 0.81–1.04 | 0.17 |
| Tumor localization | ||||||
| Right colon | Ref | Ref | ||||
| Transverse | 1.15 | 1.02–1.28 | 0.017 | 1.19 | 1.07–1.34 | 0.002 |
| Left colon | 0.74 | 0.69–0.79 | <0.001 | 0.75 | 0.69–0.8 | <0.001 |
| Rectosigmoid | 0.76 | 0.69–0.84 | <0.001 | 0.77 | 0.7–0.85 | <0.001 |
| Rectum | 0.61 | 0.57–0.66 | <0.001 | 0.61 | 0.57–0.66 | <0.001 |
| Histologic type | ||||||
| Adenocarcinoma | Ref | Ref | ||||
| Not adenocarcinoma | 2.03 | 1.84–2.23 | <0.001 | 1.95 | 1.77–2.15 | <0.001 |
| Grade | ||||||
| I–II | Ref | Ref | ||||
| III–IV | 1.89 | 1.76–2.03 | <0.001 | 1.9 | 1.77–2.04 | <0.001 |
| Unknown | 2.65 | 2.49–2.83 | <0.001 | 2.63 | 2.46–2.81 | <0.001 |
| T | ||||||
| T1-T2 | Ref | Ref | ||||
| T3-T4 | 0.65 | 0.6–0.72 | <0.001 | 0.66 | 0.6–0.73 | <0.001 |
| Unknown | 1.46 | 1.33–1.6 | <0.001 | 1.44 | 1.31–1.59 | <0.001 |
| N | ||||||
| N0-N1 | Ref | Ref | ||||
| N2 | 0.75 | 0.7–0.81 | <0.001 | 0.77 | 0.71–0.82 | <0.001 |
| Unknown | 2.07 | 1.93–2.22 | <0.001 | 2.02 | 1.88–2.17 | <0.001 |
| Tumor size | ||||||
| ≤ 45 | Ref | Ref | ||||
| 46–76 | 2.31 | 2.18–2.45 | <0.001 | 2.3 | 2.17–2.44 | <0.001 |
| >76 | 2.06 | 1.2–3.56 | 0.009 | 2.33 | 1.35–4.01 | 0.002 |
| Unknown | 1.98 | 1.81–2.16 | <0.001 | 1.96 | 1.78–2.15 | <0.001 |
| Surgery | ||||||
| Yes | Ref | Ref | ||||
| No | 2.06 | 1.26–3.37 | 0.004 | 2.02 | 1.22–3.35 | 0.006 |
| Unknown | 2.44 | 2.2–2.7 | <0.001 | 2.33 | 2.09–2.59 | <0.001 |
| Non primary surgery | ||||||
| Yes | Ref | Ref | ||||
| No | 12.35 | 11.58–13.18 | <0.001 | 10.81 | 10.12–11.54 | <0.001 |
| Unknown | 1.83 | 1.66–2.03 | <0.001 | 1.88 | 1.7–2.09 | <0.001 |
| Radiation | ||||||
| Yes | Ref | Ref | ||||
| No/Unknown | 1.59 | 1.37–1.84 | <0.001 | 1.52 | 1.31–1.76 | <0.001 |
| Chemotherapy | ||||||
| Yes | Ref | Ref | ||||
| No/Unknown | 2.6 | 2.13–3.17 | <0.001 | 2.61 | 2.14–3.19 | <0.001 |
| Bone metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 1.5 | 1.31–1.73 | <0.001 | 1.44 | 1.25–1.67 | <0.001 |
| Unknown | 1.21 | 1.13–1.29 | <0.001 | 1.25 | 1.17–1.34 | <0.001 |
| Brain metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 1.3 | 1.03–1.64 | 0.026 | 1.34 | 1.06–1.69 | 0.015 |
| Unknown | 1.23 | 1.16–1.31 | <0.001 | 1.26 | 1.18–1.34 | <0.001 |
| Liver metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 1.69 | 1.46–1.95 | <0.001 | 1.61 | 1.39–1.87 | <0.001 |
| Unknown | 1.22 | 1.13–1.33 | <0.001 | 1.25 | 1.15–1.36 | <0.001 |
| Lung metastasis | ||||||
| No | Ref | Ref | ||||
| Yes | 1.55 | 1.4–1.7 | <0.001 | 1.54 | 1.39–1.7 | <0.001 |
| Unknown | 2.2 | 2.04–2.38 | <0.001 | 2.19 | 2.03–2.37 | <0.001 |