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. 2023 Jan 3;18(1):e0279578. doi: 10.1371/journal.pone.0279578

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© 2023 Choong et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — Haematoxylin & eosin staining of tissues and immunohistochemistry staining for ACE2, TMPRSS2 and NRP1. (A) Normal kidney displays staining of the apical plasma membranes of the proximal tubules for all three proteins. G = glomerulus, arrows = examples of proximal tubules and asterisk = collecting duct (negative). (B) Clear cell renal cell carcinoma tissue shows a diffuse staining of the plasma membranes for ACE2, TMPRSS2 and NRP1. (C) Papillary renal cell carcinoma displays an apical staining pattern for all three proteins. The lower rows of the panels show higher magnification of the images above. (D) Chromophobe renal cell carcinoma displayed negative staining for ACE2 and NRP1 whereas TMPRSS2 was strongly positive in the cancer cells. Upper panel scale bar = 100μm, lower panel scale bar = 40μm. (CCRCC = clear cell renal cell carcinoma, PRCC = papillary renal cell carcinoma, CHRCC = chromophobe renal cell carcinoma).