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. Author manuscript; available in PMC: 2023 Oct 31.
Published in final edited form as: Chem Soc Rev. 2022 Oct 31;51(21):9127–9173. doi: 10.1039/d2cs00618a

Figure 10. Mechanisms of introducing covalent and non-covalent interactions in catechol-terminated hydrogels.

Figure 10.

(A) The crosslinking scheme of catechol functionalized chitosan (CHI-C) and thiolated Pluronic F127 (Plu-SH), resulting in thermosensitive in situ crosslinking at body temperature. Reprinted with permission from ref 259. Copyright 2011 American Chemical Society. (B) Schematic of the crosslinking mechanism of catechol conjugated chitosan via vanadium. Rheological characterization of a pre-polymer containing 4 wt.% CHI-C with different compositions of (C) vanadium and (D) Fe3+ ions. Reprinted with permission from 265. Copyright 2014 American Chemical Society. (E) Schematic of the mussel-inspired silk fibroin (SF)-based hydrogels, and (F) the different mechanisms of hydrogel-tissue adhesion. (G) Lap shear adhesive strength of the SF hydrogel sealant (SFT) is significantly higher than that of commercially available fibrin sealant. Reproduced with permission from ref 268. Copyright 2019, Royal Society of Chemistry.