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. Author manuscript; available in PMC: 2023 Oct 31.
Published in final edited form as: Chem Soc Rev. 2022 Oct 31;51(21):9127–9173. doi: 10.1039/d2cs00618a

Figure 16. Swelling-mediated adhesive microneedles.

Figure 16.

(A) Illustration of mechanical interlock adhesion enabled by swelling of the needle tip in the microneedle patches. (B) The fabrication process of the microneedle array using a polydimethylsiloxane (PDMS) mold and double-layered deposition of stiff PS core and swellable polystyrene-block-poly(acrylic acid) (PS-b-PAA) coating. (C) The mechanisms showing the swelling effect on the improved interlock with the tissue. (D-H) Magnified images of the fabricated needle tip on the microneedle arrays. Reprinted by permission from ref 334. Nature Publishing Group, Copyright 2013.